Childhood obesity can lead to obesity-related cardiac hypertrophy (ORCH) in adult.
ORCH was associated with increased cardiac inflammation and P38 MAPK activation.
Zinc (Zn) deficiency worsened ORCH and associated P38 MAPK activation.
Zn supplement prevented ORCH and associated P38 MAPK activation.
Block of p38 MAPK completely abolished ORCH in mice and cardiomyocytes in vitro.