The future of blood-based biomarkers for Alzheimer's disease

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• 作者：Kim Henriksen ; Sid E. O鈥橞ryant ; Harald Hampel ; John Q. Trojanowski ; Thomas J. Montine ; Andreas Jeromin ; Kaj Blennow ; Anders L枚nneborg ; Tony Wyss-Coray ; Holly Soares ; Chantal Bazenet ; Magnus Sj枚gren ; William Hu ; Simon Lovestone ; Morten A. Karsdal ; Michael W. Weiner ; Blood-Based Biomarker Interest Group
• 关键词：Blood ; Plasma ; Serum ; Biomarkers ; Alzheimer's disease
• 刊名：Alzheimer's Dementia
• 出版年：January, 2014
• 年：2014
• 卷：10
• 期：1
• 页码：115-131
• 全文大小：1033 K

文摘

Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Fluid biomarkers of AD currently provide indications of disease stage; however, they are not robust predictors of disease progression or treatment response, and most are measured in cerebrospinal fluid, which limits their applicability. With these aspects in mind, the aim of this article is to underscore the concerted efforts of the Blood-Based Biomarker Interest Group, an international working group of experts in the field. The points addressed include: (1) the major challenges in the development of blood-based biomarkers of AD, including patient heterogeneity, inclusion of the 鈥渞ight鈥?control population, and the blood-brain barrier; (2) the need for a clear definition of the purpose of the individual markers (e.g., prognostic, diagnostic, or monitoring therapeutic efficacy); (3) a critical evaluation of the ongoing biomarker approaches; and (4) highlighting the need for standardization of preanalytical variables and analytical methodologies used by the field.