刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:March 2017
年:2017
卷:167
期:Complete
页码:1-13
全文大小:2657 K
卷排序:167
文摘
Lysine deacetylases (KDACs or HDACs) are required for glucocorticoid-mediated transcriptional repression in a gene-selective fashion. KDACs promote transcriptional repression through suppression of LSD1 complex activity at selected target promoters. Pharmacological modulation of KDACs or LSD1 in treatment of disease could significantly impact glucocorticoid-regulated transcription and alter cellular response.