Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells
详细信息 查看全文
- 作者：Corinna Herza ; 1 ; Melinda-Rita Má ; rtona ; Hoai Thi Thu Trana ; 1 ; Carsten Grü ; ndemannb ; Jana Schella ; Evelyn Lamya ; 1 ; evelyn.lamy@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; arachidonic acid ; BCN ; benzyl nitrile ; BITC ; benzyl isothiocyanates ; CFSE ; carboxyfluorescein disacetate succinimidyl ester ; COX ; cyclooxygenase ; DMSO ; dimethylsulfoxid ; ELISA ; enzyme linked immunosorbent assay ; fMLP ; N-formyl-methionyl-leucyl-phenylalanine ; GLS ; glucosinolates ; ITC ; isothiocyanates ; LOX ; lipoxygenase ; LPS ; lipopolysaccharide ; LTB4 ; leukotriene B4 ; mAB ; monoclonal antibody ; MAPK ; mitogen-activated protein kinase ; PBMC ; primary human peripheral mononuclear cells ; PBS ; phospha
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：23
- 期：Complete
- 页码：135-143
- 全文大小：1318 K
文摘
- •
Benzyl ITC suppressed LPS-triggered COX pathway activation in human PBMC.
- •
Benzyl nitrile did not influence PGE2 synthesis.
- •
Benzyl ITC blocked leukotriene LTB4 release in human PBMC.
- •
Benzyl ITC mediated inhibition of ERK1/2 and c-Jun preceded COX-2 suppression.
- •
Benzyl ITC reduced the activation and function of activated T lymphocytes.