NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca2+-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin
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- 作者：Jennifer L. Sanderson1 ; Jessica A. Gorski1 ; Mark L. Dell&rsquo ; Acqua1 ; 2 ; mark.dellacqua@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：2 March 2016
- 年：2016
- 卷：89
- 期：5
- 页码：1000-1015
- 全文大小：4330 K
文摘
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AKAP150-PKA promotes GluA1 phosphorylation and CP-AMPAR synaptic recruitment in LTP
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AKAP150-PKA signaling also recruits CP-AMPARs to synapses during LTD induction
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AKAP150-calcineurin signaling rapidly removes CP-AMPARs recruited during LTD
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CP-AMPAR recruitment confers a transient meta-plastic state that promotes LTD