BDNF mRNA abundance regulated by antidromic action potentials and AP-LTD in hippocampus
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- 作者：Olena Bukalo1 ; Philip R. Lee ; R. Douglas Fields ; fieldsd@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebral spinal fluid ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; AP-LTD ; antidromic action potential-induced LTD ; (DL)-AP5 ; 2-amino-5-phosphonopentanoic acid ; BDNF ; brain-derived neurotrophic factor ; CA1 ; cornus ammonis region 1 ; CaMKII ; calcium/calmodulin kinase II ; fEPSP ; field excitatory postsynaptic potentials ; LTD ; long-term depression ; LTP ; long-term potentiation ; L-VDCC ; L-type voltage-dependent calcium channel ; (RS)-MCPG ; α-methyl-4-carboxyphenylglycine
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：635
- 期：Complete
- 页码：97-102
- 全文大小：1313 K
文摘
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BDNF gene expression in hippocampal CA1 neurons is necessary for LTD induced by antidromic stimulation (AP-LTD).
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BDNF mRNA transcripts are rapidly downregulated during AP-LTD.
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Different BDNF mRNA transcripts respond with distinct temporal profiles to antidromic stimulation.
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In contrast to antidromic stimulation, abundance in BDNF mRNA increases after LTD induced chemically by activation of L-VDCC.