Structural Mechanism for Cargo Recognition by the Retromer Complex

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• 作者：Marí ; a Lucas¹ ; ⁴ ; David C. Gershlick² ; ⁴ ; Ander Vidaurrazaga¹ ; Adriana L. Rojas¹ ; Juan S. Bonifacino² ; ^{bonifacinoj@helix.nih.gov} ; Aitor Hierro¹ ; ³ ; ⁵ ; ^{ahierro@cicbiogune.es}
• 关键词：retromer ; sorting nexins ; endosomes ; retrograde transport ; endocytic recycling ; cargo recognition ; sorting signals ; protein coats ; membrane recruitment ; membrane tubules
• 刊名：Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：167
• 期：6
• 页码：1623-1635.e14
• 全文大小：17846 K
• 卷排序：167

文摘

SNX3 participates in both retromer recruitment to membranes and cargo recognition Canonical recycling signals bind to a site at the interface between SNX3 and VPS26 Signal recognition involves a conformational change in VPS26 upon SNX3 binding The results suggest a mechanism for assembly of retromer coats on recycling tubules