Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease
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- 作者：Irina N. Shalova ; Katerina Cechalova ; Zuzana Rehakova ; Petya Dimitrova ; Elisa Ognibene ; Antonio Caprioli ; Elena V. Schmalhausen ; Vladimir I. Muronetz ; Luciano Saso
- 关键词：Glyceraldehyde-3-phosphate dehydrogenase ; Catalytic activity ; Alzheimer disease ; Animal models
- 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：1770
- 期：5
- 页码：826-832
- 全文大小：578 K
文摘
Recently, a relationship between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the β-amyloid precursor protein (βAPP) in relationship with the pathogenesis of Alzheimer's disease (AD) has been suggested. Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with β-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon γ (INFγ). We observed that GAPDH activity was significantly decreased in the brain samples from TG mice. The injection of β-amyloid, or thiorphan, an inhibitor of neprilysin involved in β-amyloid catabolism, in rat brains resulted in a pronounced reduction of the enzyme activity. The infusion of LPS and IFNγ, which can influence the progression of the AD, significantly reduced the enzyme activity.