Intrathecal lipid-specific oligoclonal IgM synthesis associates with retinal axonal loss in multiple sclerosis
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- 作者：José ; C. Á ; lvarez-Cermeñ ; oa ; josecarlos.alvarez@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author ; Francisco J. Muñ ; oz-Negreteb ; Lucienne Costa-Frossarda ; Susana Sainz de la Mazaa ; Luisa M. Villarc ; 1 ; Gema Rebolledaa ; 1
- 关键词：Axonal loss ; OCT ; IgM ; Oligoclonal bands ; Neurodegeneration ; Multiple sclerosis
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：360
- 期：Complete
- 页码：41-44
- 全文大小：220 K
文摘
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We studied CSF lipid-specific IgM antibodies (LS-OCMB) in MS patients.
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We also studied with OCT the peripapillary retinal fiber layer (RNFL) in them.
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We found RNFL thinning, reflecting retinal axonal loss, in MS vs controls (p < 0.01).
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MS patients with LS-OCMB had further reduction of RNFL vs LS-OCMB negative patients.
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This reinforces the previously found association of LS-OCMB with axonal loss in MS.