New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice

详细信息    查看全文

• 作者：Andrea Enrique^a ; ^b ; ^{andreaenrique@biol.unlp.edu.ar} ; Sofí ; a Goicoechea^a ; Rocí ; o Castañ ; o^a ; Facundo Taborda^a ; Luisa Rocha^c ; Sandra Orozco^d ; Elena Girardi^b ; Luis Bruno Blanch^a
• 关键词：Refractory epilepsy ; Animal models ; P-glycoprotein ; Drug resistance ; 3-Mercaptopropionic acid ; Mice
• 刊名：Epilepsy Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：129
• 期：Complete
• 页码：8-16
• 全文大小：1501 K
• 卷排序：129

文摘

A new model of pharmacoresistant seizure was developed in mice. In the new model animals have a high percentage of PHT and PB resistance. Resistance is linked to overexpression of Pgp. This model is an excellent alternative to the available models for the evaluation of new drugs.