Determination of 23 phthalic acid esters in food by liquid chromatography tandem mass spectrometry

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• 作者：Dunming Xu ; Xiaojun Deng ; Enhua Fang ; Xianghua Zheng ; Yu Zhou ; Liyi Lin ; Luping Chen ; Ming Wu ; Zhiqiang Huang
• 关键词：Phthalic acid esters (PAEs) ; Liquid chromatography tandem mass spectrometry (LC&ndash ; MS/MS ; Foodstuff ; QuEChERS ; SPE
• 刊名：Journal of Chromatography A
• 出版年：10 January, 2014
• 年：2014
• 卷：1324
• 期：Complete
• 页码：49-56
• 全文大小：816 K

文摘

A rapid and sensitive method was developed for the determination of 23 phthalates in food samples including milk-based products, distilled liquor, wine, beverage, grain, meat, oil, biscuit (cookie), and canned food by liquid chromatography tandem mass spectrometry (LC-MS/MS). Liquid samples were exacted by acetonitrile, while solid samples were prepared by QuEChERS or glass-based SPE methods. The 23 phthalates were separated on Poroshell 120 EC-C₁₈ column and followed by positive electrospray ionization as well as multi-reaction monitoring provided by a triple-quadrupole tandem mass spectrometer. To reduce contamination, the plastic materials were avoided in sample handling and preparation . The LODs were between 0.8 and 15 渭g kg^鈭? and LOQs were between 10 and 100 渭g kg^鈭?. By using different concentrations: 100, 500, and 1000 渭g kg^鈭?) for DINP and DIDP; 50, 100, and 1000 渭g kg^鈭? for other 21 phthalate compounds, the spiked recoveries were within 75.5-115.2% and the relative standard deviations (RSDs) were in the range of 3.2-18.9%. The proposed protocol was then applied to the analysis of 623 real samples collected from the two sides of the Taiwan Straits, and the DEHP was found in almost all samples tested in this study, with levels ranging from 0.02 to 2685 mg kg^鈭?. The present study demonstrated a rapid, sensitive, and accurate method for determining 23 phthalates in foodstuffs.