Divergences in KIR2D⁺ natural killer and KIR2D⁺CD8⁺ T-cell reconstitution following liver transplantation

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• 作者：M.R. Ló ; pez-Á ; lvarez^a ; ^d ; ^† ; ; J.A. Campillo^a ; ^d ; ^† ; ; I. Legaz^a ; R.M. Blanco-Garc&#xed ; a^a ; G. Salgado-Cecilia^a ; J.M. Bolar&#xed ; n^a ; L. Gimeno^a ; J. Gil^b ; A.M. Garc&#xed ; a-Alonso^a ; ^d ; M. Muro^a ; ^d ; M.R. Á ; lvarez-Ló ; pez^a ; ^d ; M. Miras^c ; ^d ; A. Minguela^a ; ^d ; ^{alfredo.minguela@carm.es}
• 关键词：NK cells ; CD8 T lymphocytes ; KIR2D receptors ; Liver transplantation ; Tolerance
• 刊名：Human Immunology
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：72
• 期：3
• 页码：229-237
• 全文大小：2087 K

文摘

Natural killer (NK) and CD8⁺ T cells may be active elements in the allograft response, but little is known about their role in liver transplantation. Some of these cells express killer immunoglobulin-like receptors (KIRs), which after binding specific ligands may transmit inhibitory/activating signals. In this study, circulating NK and CD8⁺ T cells expressing CD158a/h (KIR2DL1/S1) or CD158b/j (KIR2DL2/3/S²) receptors were analyzed in 142 liver recipients by flow cytometry. They were underrepresented in patients before transplantation, but following transplantation, whereas the KIR2D⁺ NK subsets experienced a late recuperation (day 365) mainly in C2-homozygous patients developing early acute rejection, recovery of the 2 CD8⁺KIR2D⁺ T cells started earlier, showing significant differences on day 365 between patients without acute rejection and those suffering from it (p = 0.004 and p < 0.0001, respectively). These differences were also evident when the human leukocute antigen-C genotypes of the recipient were considered. In conclusion, whereas the late recovery of KIR2D⁺ NK cells in C2/C2 patients appears to be linked to acute rejection, the increase in early CD8⁺KIR2D⁺ T cells in overall liver recipients correlates with a most successful early graft outcome. Therefore, monitoring of KIR2D⁺ cells appears to be a useful tool for liver transplant follow-up.