Transitional B cell subsets—a convincing predictive biomarker for allograft loss?

详细信息    查看全文

• 作者：Hannah Burton¹ ; Anthony Dorling¹ ; ^{anthony.dorling@kcl.ac.uk}
• 刊名：Kidney International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：91
• 期：1
• 页码：18-20
• 全文大小：305 K
• 卷排序：91

文摘

In this issue, Cherukuri and colleagues describe a convincing association between the proportion of transitional B lymphocyte subsets in kidney transplant recipients and long-term outcomes, and present a biologically plausible mechanism, based on differential ability of T1 and T2 cells to regulate in vitro T cell responses to explain the link. Further work is clearly needed to validate their claim that measurement of T1/T2 ratios may represent a reliable and reproducible predictive biomarker of transplant outcomes.