Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro
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- 作者：Mehmet Sarimahmuta ; 1 ; Necmiye Balikcia ; 1 ; Serap Celiklera ; scelikler@uludag.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Ferda Aria ; Engin Ulukayab ; Gurcan Guleryuza ; Mustafa Zafer Ozelc
- 关键词：Hypericum adenotrichum ; Genotoxicity ; Apoptosis ; Breast cancer
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：137-146
- 全文大小：1643 K
文摘
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The genotoxic and apoptotic potency of Hypericum adenotrichum investigated in human lymphocytes and breast cancer cells.
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Content analysis of extract of H. adenotrichum plant that is endemic to Turkey.
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Sister chromatid exchange, micronuclei, comet, MTT, ATP, ELISA assays and fluorescence imaging were performed.
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Cell type-dependent genotoxic and cytotoxic effects of H. adenotrichum in lymphocytes and cancer cells, respectively.