Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria
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- 作者：Supun M. Bakmiwewaa ; sbak7274@uni.sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Silvia Weisera ; silviaweiser@gmx.de" class="auth_mail" title="E-mail the corresponding author ; Meredith Greya ; Meredith.lorna@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Benjamin Hengb ; benjamin.heng@mq.edu.au" class="auth_mail" title="E-mail the corresponding author ; Gilles J. Guilleminb ; gilles.guillemin@mq.edu.au" class="auth_mail" title="E-mail the corresponding author ; Helen J. Balla ; helen.ball@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Nicholas H. Hunta ; nicholas.hunt@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cerebral malaria ; Astrocytes ; Interferon-gamma ; Lymphotoxin-alpha ; CXCL10
- 刊名：Cytokine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：79-86
- 全文大小：969 K
文摘
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IFN-γ and LT-α are essential for the pathogenesis of experimental cerebral malaria.
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We show that IFN-γ induced CXCL10 expression in mouse and human astrocytes.
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LT-α synergistically increased the induction of CXCL10 by IFN-γ.
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Increased cytokine receptor cross-induction may explain the synergism.
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Astrocytes may play an essential role in the development of CM by producing CXCL10.