Action of Nicotine and Ovariectomy on Bone Regeneration After Tooth Extraction in Rats

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• 作者：Giscard José ; Ribeiro Machado ; Sheila Mô ; nica Damá ; sio Dias ; Á ; lvaro Fancisco Bosco ; Tetuo Okamoto ; Joã ; o Cé ; sar Bedran de Castro ; Rita Cá ; ssia Menegati Dornelles
• 刊名：Journal of Oral and Maxillofacial Surgery
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：68
• 期：11
• 页码：2675-2681
• 全文大小：3567 K

文摘

Purpose

The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.

Materials and Methods

For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on days 7 and 14 when the alveoli were removed for further analyses.

Results

The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.

Conclusion

These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy.