Macrophage-derived microvesicles promote proliferation and migration of Schwann cell on peripheral nerve repair
详细信息 查看全文
- 作者：Chuan Zhan ; zhchuansy@163.com" class="auth_mail" title="E-mail the corresponding author ; Cheng-bin Ma ; Hong-mou Yuan ; Bao-yuan Cao ; Jia-jun Zhu
- 关键词：Schwann cell ; Nerve regeneration ; Macrophage phenotype ; Microvesicles
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：343-348
- 全文大小：901 K
文摘
- 10">
- •
10">M2 macrophages-derived MVs elevated migration and proliferation of SCs.
- •
15">M2 macrophages-derived MVs up-regulated NFG and Laminin expression of SCs.
- •
MiR-223 expression was increased in M2 macrophages-derived MVs.
- •
MiR-223 inhibitor reduced migration and proliferation of SCs co-incubated with MVs.
- •
MiR-223 inhibitor down-regulated NFG and Laminin levels of SCs co-incubated with MVs.