- 作者：Martine Mauget-FaŸ ; sse ; Pierre-LoÏ ; c Cornut ; Maddalena Quaranta El-Maftouhi ; Anita Leys
- 刊名：American Journal of Ophthalmology
- 出版年：2006
- 出版时间：December 2006
- 年：2006
- 卷：142
- 期：6
- 页码：970-975.e2
- 全文大小：1528 K
Purpose
To describe polypoidal choroidal vasculopathy as a complication of tilted disk syndrome and high myopia with staphyloma.Design
Retrospective interventional case series.
Methods
This report was a multicenter evaluation of six patients (eight eyes) with tilted disk syndrome or high myopia that was complicated by posterior staphyloma. Complete ophthalmic examination that included fluorescein angiography, optical coherence tomography (OCT), and indocyanine green angiography (ICG-A) was performed in all patients.
Results
All patients had macular abnormalities and visual loss. Fundus examination and fluorescein angiography showed typical features of tilted disk syndrome (five patients; six eyes) or high myopia (one patient; two eyes) with staphyloma that was associated with polypoidal choroidal vasculopathy. OCT and ICG-A confirmed the presence of polypoidal dilations in the choroid. Seven eyes were treated with laser photocoagulation or verteporfin-photodynamic therapy (V-PDT), although one eye did not require treatment. Visual acuity at the final visit had improved in three eyes, deteriorated in three eyes, and remained unchanged in two eyes.
Conclusion
Polypoidal choroidal vasculopathy is a potential cause of visual loss in tilted disk syndrome and high myopia. We postulate that choroidal abnormalities at the border of staphylomas induce blood-flow disturbances that are similar to those disturbances that are observed in chronic central serous chorioretinopathy, which is another condition that occasionally is associated with polypoidal choroidal vasculopathy. The pathogenesis remains unclear, and further study is required to better understand the formation of choroidal polypoidal dilations in these conditions.