Signatures of Breast Cancer Metastasis: aMENAble to Interpretation?

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• 作者：Madeleine J. Oudin¹ ; ^{mjoudin@mit.edu} ; Frank B. Gertler¹ ; ² ; ^{fgertler@mit.edu}
• 关键词：biomarker ; breast cancer ; Mena ; metastasis ; tumor microenvironment of metastasis
• 刊名：Trends in Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：3
• 期：1
• 页码：7-9
• 全文大小：705 K
• 卷排序：3

文摘

MenaINV, an isoform of the motility regulator protein Mena, contributes to prometastatic phenotypes. Tumor microenvironment of metastasis (TMEM), a three-cell structure associated with intravasation, contains a stationary Mena-expressing tumor cell. TMEM density and MenaINV expression both correlate with poor clinical outcome in breast cancer patients. However, is MenaINV involved in TMEM assembly and function?