A study of voice profiles and acoustic signs in patients with Parkinson¡¯s disease in North India

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• 作者：Jayam P Lazarus ; Deepti Vibha ; K.K. H ; a ; Sumit Singh ; Vinay Goyal ; Trilochan Srivastava ; Vijay Aggarwal ; Madhuri Behari
• 关键词：Disease progression ; Parkinson&rsquo ; s disease ; Speech disorder ; Vaghmi
• 刊名：Journal of Clinical Neuroscience
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：19
• 期：8
• 页码：1125-1129
• 全文大小：158 K

文摘

We aimed to study the voice profiles of patients with Parkinson¡¯s disease (PD) and correlate the profiles with disease severity. A total of 133 patients with PD were recruited. Patients were divided into two groups: Group 1 with a Unified Parkinson¡¯s Disease Rating Scale (UPDRS) score of ?45; and Group 2 with a UPDRS >45. Speech was analyzed using the Indian Speech and Hearing Association (ISHA) articulation assessment and Vaghmi software. A total of 87 patients (65.41 % ) reported a history of speech problems. Examination revealed slow reading speed (64.7 % of patients), hoarseness of voice (60.2 % ), articulatory defect (39.8 % ) and jerky speech (32.3 % ) as common abnormalities. Misarticulation was most often observed among the labial (42.1 % ), followed by lingual and palatal syllables. The ISHA articulation test demonstrated significant differences in mean numbers of words distorted (p < 0.001) and intelligible speech (p = 0.004) between patients with early and advanced PD. Vaghmi software analysis (Speech and Voice Systems, Bangalore, India) also revealed significant difference between the two groups in maximum phonation duration (p = 0.034), inability to phonate (noiseless speech, Z; p = 0.002) and the mean noise-to-noiseless speech (S/Z) ratio (p = 0.006).