Markedly disturbed sleep in medically refractory compared to controlled epilepsy - A clinical and polysomnography study

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• 作者：Paresh Zanzmera ; Garima Shukla ; Anupama Gupta ; Hariom Singh ; Vinay Goyal ; Achal Srivastava ; Madhuri Behari
• 关键词：Medically refractory ; Epilepsy ; Polysomnography ; Sleep ; Arousals
• 刊名：Seizure
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：21
• 期：7
• 页码：487-490
• 全文大小：146 K

文摘

Purpose

To evaluate sleep disturbances or sleep related events and their characteristics among patients with medically refractory epilepsy, compared to those with controlled epilepsy.

Methods

In a prospective case-controlled study, patients of medically refractory and controlled epilepsy were recruited and history pertaining to epilepsy and sleep related events and Epworth sleepiness scores were recorded and all patients underwent over night polysomnography.

Results

Among 40 patients, 20 with medically refractory (Group 1) and 20 with controlled epilepsy (Group 2) (median age 18, range 10-35 years), the self reported sleep parameters in Group 1 patients were found to be significantly different as compared to Group 2, in terms of the duration of night time sleep, day time sleep, day time nap frequency, total sleep hours per day, excessive daytime sleepiness (EDS)(45 % vs. 15 % ) and average sleep hours over the week prior to polysomnography. On PSG, Group 1 patients showed significantly less total sleep time [340.4 min (147-673) vs. 450.3 min (330-570)] with delayed sleep latency and REM latency, poor sleep efficiency [80.45 (40.5-98.0) vs. 95.45 (88.4-99.7)] and frequent arousals and wake after sleep onset (WASO) compared to Group 2 patients. Four patients (20 % ) in Group 1 compared to none in Group 2 were found to have mild obstructive sleep apnea.

Conclusions

Our results indicate that medically refractory epilepsy patients believe that they spend more time sleeping, in contrast to the documented shorter sleep duration on polysomnography. This difference between perceived and actual sleep seems, by their data, to arise mainly from sleep fragmentation, disturbed architecture and the interesting finding of associated sleep apnea among the medically refractory epilepsy patients.