Asymmetric synthesis of chiral amine in organic solvent and in-situ product recovery for process intensification: A case study

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• 作者：Yamini Satyawali ; ^{Yamini.satyawali@vito.be} ; Ehiaze Ehimen ; Lieve Cauwenberghs ; Miranda Maesen ; Pieter Vandezande ; Winnie Dejonghe
• 关键词：ω-Transaminase ; Chiral amines ; Process intensification ; Membrane contactor ; Nanofiltration
• 刊名：Biochemical Engineering Journal
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：117
• 期：part_PB
• 页码：97-104
• 全文大小：2003 K
• 卷排序：117

文摘

Transamination was conducted in 100% organic solvent (n-heptane). Increased the substrate concentration to 2.5-fold higher than its solubility in aqueous phase. After 72 h of operation in membrane contactor, 99% substrate conversion was observed.