Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus

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• 作者：Glaucia V. Novak^a ; ¹ ; Mariana Marques^a ; ¹ ; Verena Balbi^a ; Natali W.S. Gormezano^a ; ^b ; Ká ; tia Kozu^a ; Ana P. Sakamoto^c ; Rosa M.R. Pereira^b ; Maria T. Terreri^c ; Claudia S. Magalh&atilde ; es^d ; Andressa Guariento^e ; Adriana M.E. Sallum^a ; Roberto Marini^f ; Virginia Paes Leme Ferriani^g ; Cá ; ssia Maria Barbosa^h ; Tâ ; nia Caroline Monteiro de Castroⁱ ; Valé ; ria C. Ramos^j ; Eloisa Bonfá ; ^b ; Clovis A. Silva^a ; ^b ; ^{clovisaasilva@gmail.com}
• 关键词：Anti-Ro/SSA autoantibodies ; Anti-La/SSB autoantibodies ; Sjö ; gren syndrome and childhood-systemic lupus erythematosus ; Multicenter cohort
• 刊名：Autoimmunity Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：16
• 期：2
• 页码：132-135
• 全文大小：210 K
• 卷排序：16

文摘

To our knowledge there are no studies assessing anti-Ro/SSA and anti-La/SSB autoantibodies in a large population of childhood-systemic lupus erythematosus (cSLE) patients.MethodsThis was a retrospective multicenter cohort study performed in 10 Pediatric Rheumatology services, S&atilde;o Paulo state, Brazil. Anti-Ro/SSA and anti-La/SSB antibodies were measured by enzyme linked immunosorbent assay (ELISA) in 645 cSLE patients.ResultsAnti-Ro/SSA and anti-La/SSB antibodies were evidenced in 209/645 (32%) and 102/645 (16%) of cSLE patients, respectively. Analysis of cSLE patients with and without anti-Ro/SSA antibodies revealed higher frequencies of malar rash (79% vs. 71%, p = 0.032), photosensitivity (73% vs. 65%, p = 0.035), cutaneous vasculitis (43% vs. 35%, p = 0.046) and musculoskeletal involvement (82% vs. 75%, p = 0.046) in spite of long and comparable disease duration in both groups (4.25 vs. 4.58 years, p = 0.973). Secondary Sjögren syndrome was observed in only five patients with this antibody (2.5% vs. 0%, p = 0.0035), two of them with concomitant anti-La/SSB. The presence of associated autoantibodies: anti-Sm (50% vs. 30%, p < 0.0001), anti-RNP (39% vs. 21%, p < 0.0001) and anti-ribossomal P protein (46% vs. 21%, p = 0.002) was also significantly higher in patients with anti-Ro/SAA antibodies. Further evaluation of cSLE patients with the presence of anti-La/SSB antibodies compared to those without these autoantibodies showed that the frequency of alopecia (70% vs. 51%, p = 0.0005), anti-Sm (59% vs. 31%, p < 0.0001) and anti-RNP (42% vs. 23%, p < 0.0001) were significantly higher in the former group.ConclusionsOur large multicenter cohort study provided novel evidence in cSLE that anti-Ro/SSA and/or anti-La/SSB antibodies were associated with mild manifestations, particularly cutaneous and musculoskeletal. Secondary Sjögren syndrome was rarely observed in these patients, in spite of comparable frequencies of anti-Ro/SSA and/or anti-La/SSB reported for adult SLE.