Caught between triterpene- and steroid-metabolism: 4¦Á-Carboxylic pregnane-derivative from the marine alga-derived fungus Phaeosphaeria spartinae

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• 作者：Mahmoud Fahmi Elsebai ; Stefan Kehraus ; Gabriele M. K?nig
• 关键词：Phaeosphaeria spartinae ; Pregnenolone ; Natural products ; Spartopregnenolone
• 刊名：Steroids
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：78
• 期：9
• 页码：880-883
• 全文大小：341 K

文摘

Investigation of the fungus Phaeosphaeria spartinae, an endophyte of the marine red alga Ceramium sp., led to the isolation of spartopregnenolone (1), a metabolite whose structure includes features of triterpenes and steroids, i.e. a ¦¤^8,9 double bond as occurring in lanosterol type triterpenoids, a carboxyl group at C-4 which is characteristic for intermediates on the way from triterpenes to steroids and an acetyl side chain as typical for pregnane type steroids. The unusual structure of compound 1 was established from extensive spectroscopic investigations and is best described as a 4¦Á-carboxy-8,9-pregnene derivative.