An Emerging Regulatory Landscape for Skeletal Development

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• 作者：Hironori Hojo¹ ; Andrew P. McMahon² ; Shinsuke Ohba¹ ; ^{ohba@bioeng.t.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cell specification ; chondrocytes ; gene regulatory networks ; osteoblast ; skeletal development ; transcriptional regulators
• 刊名：Trends in Genetics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：12
• 页码：774-787
• 全文大小：1993 K

文摘

Skeletal development creates the physical framework that shapes our body and its actions. In the past two decades, genetic studies have provided important insights into the molecular processes at play, including the roles of signaling pathways and transcriptional effectors that coordinate an orderly, progressive emergence and expansion of distinct cartilage and bone cell fates in an invariant temporal and spatial pattern for any given skeletal element within that specific vertebrate species. Genome-scale studies have provided additional layers of understanding, moving from individual genes to the gene regulatory landscape, integrating regulatory information through cis-regulatory modules into cell type-specific gene regulatory programs. This review discusses our current understanding of the transcriptional control of mammalian skeletal development, focusing on recent genome-scale studies.