IL-4 Rapidly Produced by Vβ4 Vα8 CD4⁺ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

详细信息    查看全文

• 作者：Pascal Launois ; Ivan Maillard ; Sabine Pingel ; Kristin G. Swihart ; Ioannis Xé ; narios ; Hans Acha-Orbea ; Heidi Diggelmann ; Richard M. Locksley ; H. Robson MacDonald ; Jacques A. Louis
• 刊名：Immunity
• 出版年：1997
• 出版时间：1 May 1997
• 年：1997
• 卷：6
• 期：5
• 页码：541-549
• 全文大小：150 K

文摘

BALB/c mice develop aberrant T helper 2 (Th2) responses and suffer progressive disease after infection with Leishmania major. These outcomes depend on the production of interleukin-4 (IL-4) early after infection. Here we demonstrate that the burst of IL-4 mRNA, peaking in draining lymph nodes of BALB/c mice 16 hr after infection, occurs within CD4⁺ T cells that express Vβ4 Vα8 T cell receptors. In contrast to control and Vβ6-deficient BALB/c mice, Vβ4-deficient BALB/c mice were resistant to infection, demonstrating the role of these cells in Th2 development. The early IL-4 response was absent in these mice, and T helper 1 responses occurred following infection. Recombinant LACK antigen from L. major induced comparable IL-4 production in Vβ4 Vα8 CD4⁺ cells. Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of Vβ4 Vα8 CD4⁺ T cells after cognate interaction with a single antigen from this complex organism.