The study included 250 consecutive diabetic patients undergoing coronary angiography with or without PCI. Those enrolled during the first 7 months of the study received ioversol and those enrolled during the following 11 months received iodixanol. The primary study endpoint was the incidence of CIN. Secondary objectives were to identify independent predictors of CIN and to determine the mean increase in SCr 72 hours after contrast injection.
The overall incidence of CIN was 5.6 % . The incidence of CIN was significantly lower with iodixanol than with ioversol (2.5 % vs 8.3 % , respectively; odds ratio [OR] = 0.255; 95 % confidence interval [CI], 0.068–0.952; P=.047). A low estimated glomerular filtration rate (60.8 [29] mL/min per 1.73 m2 in those with CIN vs 75.3 [25] mL/min per 1.73 m2 in those without; OR=0.975; 95 % CI, 0.952–0.997; P=.03) and ioversol use were independent predictors of CIN.
In diabetic patients undergoing diagnostic coronary angiography with or without PCI, the iso-osmolar contrast medium iodixanol was associated with a lower incidence of CIN than low-osmolar ioversol.