Extensively drug-resistant tuberculosis treatment outcome in Iran: a case series of seven patients

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• 作者：Mohammad R. Masjedi ; Payam Tabarsi ; Parvaneh Baghaei ; Sara Jalali ; Parisa Farnia ; Ehsan Chitsaz ; Majid Amiri ; Davood Mansouri ; Ali A. Velayati
• 关键词：Tuberculosis ; XDR ; Outcome
• 刊名：International Journal of Infectious Diseases
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：14
• 期：5
• 页码：e399-e402
• 全文大小：102 K

文摘

Background

Extensively drug-resistant tuberculosis (XDR-TB) has recently been identified as a major threat to global health. XDR-TB poses a risk of higher failure rates and death during TB treatment. We report herein the outcomes of XDR-TB in patients treated with the standardized regimen in Iran.

Patients and methods

Between 2002 and 2006, seven patients were diagnosed with XDR-TB. All patients were treated with the standardized second-line regimen containing cycloserine, prothionamide, amikacin, and ofloxacin. First-line drugs, such as ethambutol and pyrazinamide, were added to the regimen if drug susceptibility testing showed sensitivity to these drugs.

Results

Four (57.1 % ) patients were male. All seven patients were HIV-negative. The patient age range was 22–79 years. Of the seven cases, the final outcome was ‘cure’ in two (28.6 % ), ‘relapse’ in one, ‘treatment failure’ in one, and ‘death’ in two; the outcome for one patient was unknown.

Conclusion

Our study shows a poor prognosis in patients with XDR-TB. This indicates the necessity of detecting XDR-TB cases earlier, as well as the need to gain access to more second-line agents. This is particularly important in resource-limited settings in order to administer individualized regimens.