Single administration of soluble epoxide hydrolase inhibitor suppresses neuroinflammation and improves neuronal damage after cardiac arrest in mice
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- 作者：Noriko Taguchi ; taguchine@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shin Nakayama ; Makoto Tanaka
- 关键词：CA ; cardiac arrest ; CPR ; cardiopulmonary resuscitation ; EETs ; epoxyeicosatrienoic acids ; HMGB1 ; high-mobility group box protein-1 ; IBA1 ; ionized calcium-binding adaptor molecule-1 ; Neu-N ; neuronal nuclei ; NFκB ; nuclear factor κB ; sEH ; soluble epoxide hydrolase ; TNF-α ; tumor necrosis factor-α ; ROSC ; recovery of spontaneous circulation
- 刊名：Neuroscience Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：56-63
- 全文大小：1431 K
文摘
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sEH inhibitor protected the hippocampal neuron at 7 days after cardiac arrest.
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sEH inhibitor suppressed systemic inflammation after cardiac arrest.
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sEH inhibitor suppressed neuroinflammation in hippocampus at 7 days after ischemia.