Induction of OAS gene family in HIV monocyte infected patients with high and low viral load
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- 作者：P. Fagoneb ; G. Nunnaria ; F. Lazzarab ; A. Longob ; D. Cambriab ; G. Distefanob ; M. Palumbob ; F. Nicolettib ; L. Malaguarnerab ; M. Di Rosab ; mdirosa@unict.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：OAS1 ; OAS2 ; OAS3 ; OASL ; Monocyte ; HIV-1
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：66-73
- 全文大小：2015 K
文摘
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The OAS gene family is significantly upregulated in monocyte of HIV-1 patients with HVL and LVL.
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The IFN Type 1 and 2 modulate significantly the OAS gene expression.
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The expression of OAS genes inversely correlate to CD4 count in HIV-1 patients.
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OAS genes are sensitive to viral load in the monocytes of HIV-1 patients.