NFAT inhibitor tributylhexadecylphosphoniumbromide, ameliorates high fructose induced insulin resistance and nephropathy
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- 作者：Maitri Sanghavi1 ; smaitri2010@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Malek Vajir1 ; malekvajir@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sandeep Kumar1 ; sandyjan87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kulbhushan Tikoo ; 1 ; tikoo.k@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：THPB ; Insulin resistance ; Apoptosis ; NFATc4 ; Diabetic nephropathy
- 刊名：Chemico-Biological Interactions
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：240
- 期：Complete
- 页码：268-277
- 全文大小：3816 K
文摘
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HFrD-induced IR and renal injury is associated with altered NFATc4/PTEN signalling.
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NFATc4 inhibition by THPB improves acute ANG II responses.
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NFAT inhibition by THPB represses the processes of renal fibrosis and inflammation.
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THPB also prevents foot process effacement and renal apoptosis in HFrD rats.