Differential regulation of angiotensin converting enzyme 2 and nuclear factor-κB by angiotensin II receptor subtypes in type 2 diabetic kidney
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- 作者：Anuradha Pandey ; Santosh Kumar Goru ; Almesh Kadakol ; Vajir Malek ; Anil Bhanudas Gaikwad ; anil.gaikwad@pilani.bits-pilani.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：AT1 receptor ; AT2 receptor ; ACE2 ; NF-кB signalling pathway ; Oxidative stress
- 刊名：Biochimie
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：118
- 期：Complete
- 页码：71-81
- 全文大小：2907 K
文摘
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A non-genetic model for type 2 diabetic nephropathy was developed and validated.
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AT1R and AT2R antagonists’ effects were studied on NF-κB activity and ACE2.
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We found that the activation of NF-κB signalling pathway is mediated through AT1R.
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The blockade of AT2R was found to upregulate ACE2 expression.