H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats

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• 作者：Anuradha Pandey ; Santosh Kumar Goru ; Almesh Kadakol ; Vajir Malek ; Nisha Sharma ; Anil Bhanudas Gaikwad ; ^{anil.gaikwad@pilani.bits-pilani.ac.in}
• 关键词：Type 2 diabetic nephropathy ; Angiotensin II receptors ; Macrophage infiltration ; Fibrosis ; H2A lysine 119 monoubiquitination
• 刊名：Biochimie
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：131
• 期：Complete
• 页码：68-76
• 全文大小：2276 K
• 卷排序：131

文摘

Telmisartan improves and PD123319 worsens diabetic nephropathy progression. Telmisartan reduces and PD123319 elevates monocyte infiltration and renal fibrosis. H3 acetylation and H2AK119Ub are increased by PD123319 and reduced by Telmisartan. Telmisartan reduces occupancy of H2AK119Ub at Mcp1 and Tgfb1 promoters.