Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents

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• 作者：Amarender Reddy Ellanki^a ; ^e ; Aminul Islam^a ; Veera Swamy Rama^a ; Ranga Prasad Pulipati^a ; D. Rambabu^b ; ^c ; G. Rama Krishna^d ; C. Malla Reddy^d ; K. Mukkanti^e ; G.R. Vanaja^f ; Arunasree M. Kalle^f ; K. Shiva Kumar^b ; Manojit Pal^b ; ^{manojitpal@rediffmail.com}
• 关键词：Click chemistry ; Azide ; Alkyne ; Quinoline ; Cancer
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：15 May, 2012
• 年：2012
• 卷：22
• 期：10
• 页码：3455-3459
• 全文大小：2339 K

文摘

A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et₃N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells.