Six-year experience: long-term disease control outcomes for partial breast irradiation using MammoSite balloon brachytherapy

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• 作者：Jennifer L. Harper ; John M. Watkins ; A. Jason Zauls ; Amy E. Wahlquist ; Elizabeth Garrett-Mayer ; Megan K. Baker ; David J. Cole ; Anthony E. Dragun ; Joseph M. Jenrette III
• 关键词：Breast cancer ; MammoSite ; Accelerated partial breast irradiation ; Breast conservation
• 刊名：The American Journal of Surgery
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：199
• 期：2
• 页码：204-209
• 全文大小：397 K

文摘

Background

This report describes estimated 4-year tumor bed and ipsilateral breast recurrence-free intervals, event-free survival, disease-specific survival, and overall survival in a cohort of MammoSite brachytherapy (MBT) patients with mature follow-up treated at a single institution over a 6-year period.

Methods and Materials

An analysis of MBT cases was performed by using a prospectively collected quality-assurance database, departmental chart review, and electronic medical records. Patient-, tumor-, treatment-, and outcome-specific data were extracted and recorded into a research database. Patients were eligible for inclusion in this analysis if they were at least 6 months post-MBT.

Results

From May 2002 through March 2008, 111 MBT patients have been treated and were eligible for the present analysis. With a median follow-up of 46 months, the estimated 4-year outcomes for the entire cohort were tumor bed control 99 % , ipsilateral breast control 95 % , event-free survival 88 % , disease-specific survival 97 % , and overall survival 92 % .

Conclusions

The present study shows low rates of local and ipsilateral breast disease failure in a well-defined cohort of MBT patients with mature follow-up.