Characterization of TistH, a multifunctional peptide from the scorpion Tityus stigmurus: Structure, cytotoxicity and antimicrobial activity
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- 作者：Richele J.A. Machadoa ; b ; André ; ia B. Estrelaa ; Ana K.L. Nascimentob ; Menilla M.A. Meloa ; Manoela Torres-Rê ; goa ; Edeltrurdes O. Limac ; Hugo A.O. Rochab ; Eneas Carvalhod ; Arnó ; bio A. Silva-Juniora ; Matheus F. Fernandes-Pedrosaa ; b ; mpedrosa@ufrnet.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Scorpion venom ; Bioactive peptide ; Antimicrobial ; Circular dichroism
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：362-370
- 全文大小：1792 K
文摘
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TistH revealed structure rich in α-helix as resolved by circular dichroism.
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The peptide was not cytotoxic and did not show in vivo inflammatory activity.
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The peptide presented antimicrobial activity capable of inhibiting fungal growth.
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TistH is a peptide potentially safe to be used as a template for therapeutic agents.