Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival

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• 作者：David Cerezo¹ ; Antonio J. Ruiz-Alcaraz¹ ; Miriam Lencina-Guardiola ; Manuel Cá ; novas ; Pilar Garc&iacute ; a-Peñ ; arrubia ; Inmaculada Mart&iacute ; nez-Ló ; pez ; Elena Mart&iacute ; n-Orozco ; ^{emartin@um.es}
• 关键词：Leukemic cells ; MDR ; P-glycoprotein ; Cold-stress ; Collateral sensitivity ; MAPK
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：162-170
• 全文大小：1391 K
• 卷排序：30

文摘

Cold stress-induces collateral sensitivity in MDR leukemic cells. P-gp, modifies the activation profile of MAPK in leukemic cells under hypothermia. P-gp-expressing cells show attenuated JNK signaling under cold stress conditions. JNK and ERK exert a temperature-dependent dual role in MDR cells survival. A dynamic model featuring a JNK-positive feedback loop is proposed.