Retrospective data from 152 pregnancies of 132 women with MS were collected by the physician in charge of the case. All data were entered into a specific file for qualitative and quantitative statistical analysis.
From the total group of patients, 89 pregnancies occurred without any exposure to MS drugs, while 61 pregnancies occurred with at least eight weeks of exposure to MS immunomodulatory drugs. The rate of obstetric and neonatal complications was similar in both groups, except for the newborn weight and height which was smaller for mothers receiving medications. Mothers¡¯ post-delivery relapse rate and EDSS scores in the follow-up period were significantly higher in the absence of treatment.
It is possible that, with further such supportive data, international guidelines on MS treatment in young women who intend to get pregnant may need to be revised.