- 作者：Francesco Sofi ; Rossella Marcucci ; S ; ra Fedi ; Barbara Giambene ; Andrea Sodi ; Ugo Menchini ; Gian Franco Gensini ; Rosanna Abbate ; Domenico Prisco
- 关键词：Retinal vein occlusion ; Lipoprotein (a) ; Risk factor ; Thrombosis
- 刊名：Atherosclerosis
- 出版年：2010
- 出版时间：May 2010
- 年：2010
- 卷：210
- 期：1
- 页码：278-281
- 全文大小：170 K
IntroductionRetinal vein occlusion (RVO) is one of the most common retinal vascular disorders affecting ocular vessels. Few studies, with conflicting results and conducted in limited study populations, have hypothesised the role of high levels of lipoprotein (a) [Lp(a)] in the occurrence of RVO. The aim of this study was to investigate, in a large group of RVO patients, the role of such an emerging thrombophilic parameter on the pathogenesis of RVO.Materials and methods
We compared 262 patients [median age: 66 years (15–88); 122 M, 140 F] with 262 age- and sex-comparable healthy subjects.
Results
Circulating concentrations of Lp(a) were found to be significantly different in patients when compared to healthy subjects [189 (60–1898) mg/L vs. 119.5 (6–1216) mg/L; p < 0.0001, respectively]. No significant differences were observed relating to the different types of occlusion (central or branch occlusion). In order to investigate the possible association between high Lp(a) levels and the disease we performed a logistic regression analysis. In the univariate analysis, Lp(a) levels > 300 mg/L were found to be associated with an increased risk of RVO (OR: 2.39, 95 % CI 1.39–3.59; p < 0.0001). Following this, three models of multivariate analysis were performed, firstly by adjusting for age, gender, and traditional cardiovascular risk factors, secondly for triglycerides and thirdly for homocysteine levels. In all the models, Lp(a) levels > 300 mg/L confirmed their role as a risk factor for RVO [first model, OR: 2.15 (95 % CI 1.39–3.32), p = 0.0001; second model, OR: 3.11 (95 % CI 1.77–5.62), p < 0.00001; third model, OR: 3.48 (95 % CI 1.88–6.43), p < 0.00001].
Conclusions
This study reports that, in a large population of RVO patients, high Lp(a) concentrations are significantly related to RVO, independent from other traditional and emerging risk factors, suggesting that they may play a role in its pathogenesis.