5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats
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- 作者：Renata Ferreiraa ; c ; Marcus Lira Brandã ; oa ; c ; Manoel Jorge Nobrea ; b ; c ; mjnes@usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anxiety-like behavior ; Trait anxiety ; Prelimbic cortex ; Female rats ; Ovarian hormones ; Serotonin ; Conditioned fear
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：84-96
- 全文大小：1496 K
文摘
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Expression of learned fear LA and HA female rats is dependent on hormonal status.
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In HA females, increases on hormonal tonus reduce fear.
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This increase is dependent from 5-HT mechanisms of the prelimbic cortex.
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Fear intensity seems dependent from drops on progesterone levels.
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In contrast to HA, LA females seems to be insensitive to prelimbic-5-HT modulation.