Dosimetry audit for a multi-centre IMRT head and neck trial

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• 作者：Catharine H. Clark ; Vibeke Nordmark Hansen ; Hannah Chantler ; Craig Edwards ; Hayley V. James ; Gareth Webster ; Elizabeth A. Miles ; M. Teresa Guerrero Urbano ; Shree A. Bhide ; A. Margaret Bidmead ; Christo
• 关键词：IMRT ; Dosimetry ; Quality assurance ; Phase III trial
• 刊名：Radiotherapy and Oncology
• 出版年：2009
• 出版时间：October 2009
• 年：2009
• 卷：93
• 期：1
• 页码：102-108
• 全文大小：355 K

文摘

Background and purpose

PARSPORT was a multi-centre randomised trial in the UK which compared Intensity-Modulated Radiotherapy (IMRT) and conventional radiotherapy (CRT) for patients with head and neck cancer. The dosimetry audit goals were to verify the plan delivery in participating centres, ascertain what tolerances were suitable for head and neck IMRT trials and develop an IMRT credentialing program.

Materials and methods

Centres enrolling patients underwent rigorous quality assurance before joining the trial. Following this each centre was visited for a dosimetry audit, which consisted of treatment planning system tests, fluence verification films, combined field films and dose point measurements.

Results

Mean dose point measurements were made at six centres. For the primary planning target volume (PTV) the differences with the planned values for the IMRT and CRT arms were −0.6 % (1.8 % to −2.4 % ) and 0.7 % (2.0 % to −0.9 % ), respectively. Ninety-four percent of the IMRT fluence films for individual fields passed gamma criterion of 3 % /3 mm and 75 % of the films for combined fields passed gamma criterion 4 % /3 mm (no significant difference between dynamic delivery and step and shoot delivery).

Conclusions

This audit suggests that a 3 % tolerance could be applied for PTV point doses. For dose distributions tolerances of 3 % /3 mm on individual fields and 4 % /3 mm for combined fields are proposed for multi-centre head and neck IMRT trials.