Rheological investigation on hyaluronan–fibrinogen interaction

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• 作者：Marguerite Rinaudo
• 关键词：Electrostatic complex ; Hyaluronan– ; fibrinogen complex ; Rheology
• 刊名：International Journal of Biological Macromolecules
• 出版年：2008
• 出版时间：1 December 2008
• 年：2008
• 卷：43
• 期：5
• 页码：444-450
• 全文大小：604 K

文摘

This paper concerns the interaction between hyaluronan and fibrinogen as model for protein–polysaccharide interaction. From rheological investigation, it is shown that a 3D physical network is promoted by mixing the two components; the mechanism is attributed to electrostatic interactions. The influences of the molecular weight and of the hyaluronan concentration are examined; the loose interaction obtained for addition of small amount of soluble protein induces a non-Newtonian behaviour which may be in direct relation with the behaviour observed previously on synovial fluids.