Loss of 10q26.1–q26.3 in association with 7q34–q36.3 gain or 17q24.3–q25.3 gain predict poor outcome in pediatric medulloblastoma

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• 作者：Annalisa Pezzolo^a ; ¹ ; ^{annalisapezzolo@ospedale-gaslini.ge.it"" rel=""nofollow} ; Simona Coco^b ; ¹ ; ^{simona.coco@istge.it"" rel=""nofollow} ; Alessandro Raso^c ; ^{rasoale@yahoo.it"" rel=""nofollow} ; Federica Parodi^a ; ^{federicaparodi@ospedale-gaslini.ge.it"" rel=""nofollow} ; Angela Pistorio^d ; ^{angelapistorio@ospedale-gaslini.ge.it"" rel=""nofollow} ; Francesca Valdora^e ; ^{francesca.valdora@istge.it"" rel=""nofollow} ; Valeria Capra^c ; ^{valeriacapra@ospedale-gaslini.ge.it"" rel=""nofollow} ; Massimo Zollo^f ; ^{zollo@ceinge.unina.it"" rel=""nofollow} ; Simona Aschero^g ; ^{simona.aschero@unito.it"" rel=""nofollow} ; Eleonora Basso^g ; ^{eleonora.basso@unito.it"" rel=""nofollow} ; Armando Cama^c ; ^{armandocama@ospedale-gaslini.ge.it"" rel=""nofollow} ; Paolo Nozza^h ; ^{paolonozza@ospedale-gaslini.ge.it"" rel=""nofollow} ; Claudio Gambini^h ; ^{claudiogambini@ospedale-gaslini.ge.it"" rel=""nofollow} ; Giuseppe Cinalliⁱ ; ^{giuseppe.cinalli@gmail.com"" rel=""nofollow} ; Maria Luisa Garr&#xe8 ; ^c ; ^j ; ^{mluisagarre@ospedale-gaslini.ge.it"" rel=""nofollow} ; Achille Iolascon^f ; ^{iolascon@ceinge.unina.it"" rel=""nofollow} ; Vito Pistoia^a ; ^{vitopistoia@ospedale-gaslini.ge.it"" rel=""nofollow} ; Gian Paolo Tonini^b ; ^{gianpaolo.tonini@istge.it"" rel=""nofollow}
• 关键词：Medulloblastoma ; CGH ; Chromosomal imbalances ; FISH ; LOH
• 刊名：Cancer Letters
• 出版年：2011
• 出版时间：28 September 2011
• 年：2011
• 卷：308
• 期：2
• 页码：215-224
• 全文大小：640 K

文摘

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1–q26.3 loss combined with 17q24.3–q25.3 gain and/or 7q34–q36.3 gain in tumors predicted poor patient’s survival. A minimal deleted region of 14.12 cM at 10q26.1–q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1–q26.3 loss plus 17q24.3–q25.3 gain and/or 7q34–q36.3 gain associations.