Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women

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• 作者：Patrí ; cia Fá ; tima Souza Novais^a ; Thabata Koester Weber^a ; ^b ; Ney Lemke^b ; Rozangela Verlengia^c ; Alex Harley Crisp^a ; ^{alexharleycrisp@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Irineu Rasera-Junior^d ; Maria Rita Marques de Oliveira^a ; ^b ; ^{mrmolive@ibb.unesp.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Obesity ; Gene polymorphism ; Bariatric surgery ; Weight loss
• 刊名：Obesity Research & Clinical Practice
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：10
• 期：6
• 页码：724-727
• 全文大小：378 K

文摘

This study aimed to investigate the association between twelve gene polymorphisms and body weight loss, 12 months after Roux-en-Y gastric bypass (RYGB) surgery. Three hundred and fifty-one obese women participated in this study. The statistical software WEKA was used to identify which gene polymorphisms were potential predictors of postoperative percentage of excess weight loss (%EWL). Our results indicate that the only gene polymorphism that predicted %EWL was rs3813929, which is related to the serotonin receptor gene (5-HT2C). Therefore, the 5-HT2C gene polymorphism rs3813929 (more specifically, the TT genotype) predicted greater %EWL 12 months after RYGB surgery among female patients.