Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing

详细信息    查看全文

• 作者：Micaela Giuliana Goldschmidt ; Mirta Fabiana Villarreal ; Delfina de Ach谩val ; Lucas Javier Drucaroff ; Elsa Yol ; a Costanzo ; Mariana Nair Castro ; Jaime Pahissa ; Joan Camprodon ; Charles Nemeroff ; Salvador Mart铆n Guinjoan
• 关键词：fMRI ; Schizophrenia ; Siblings ; Personality ; Cluster B ; Temporo parietal junction
• 刊名：Psychiatry Research: Neuroimaging
• 出版年：30 January, 2014
• 年：2014
• 卷：221
• 期：1
• 页码：30-36
• 全文大小：751 K

文摘

Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance.