Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease
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- 作者：Evelyn Ferria ; b ; 1 ; evelyn.ferri@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Beatrice Arosioa ; c ; 1 ; Claudio D'Addariod ; e ; Daniela Galimbertic ; f ; Cristina Gussagoa ; Mariangela Puccid ; Martina Casatia ; b ; Chiara Fenoglioc ; f ; Carlo Abbatec ; Paolo Dionigi Rossic ; Elio Scarpinic ; f ; Mauro Maccarronee ; g ; Daniela Maria ; c
- 关键词：Neurodegeneration ; Frontotemporal dementia ; Alzheimer's disease ; Pin1 ; Methylation ; Peripheral marker
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：362
- 期：Complete
- 页码：283-286
- 全文大小：230 K
文摘
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Frontotemporal dementia (FTD) and Alzheimer disease (AD) show fibrillar aggregates.
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Pin1 facilitates tau dephosphorylation playing a neuroprotective function.
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A higher methylation in three CpG sites at PIN1 promoter was seen in FTD patients.
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We found a lower gene expression of Pin1 in FTD patients than AD patients.
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Pin1 has an important but distinct involvement in these two types of dementia.