Involvement of the AATn polymorphism of the CNR1 gene in the efficiency of procedural learning in humans

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• 作者：Alejandra E. Ruiz-Contreras^a ; ^f ; ^{aleruiz@servidor.unam.mx} ; Maribel Delgado-Herrera^a ; Paola A. Garc&#xed ; a-Vaca^a ; Georgina A. Almeida-Rosas^a ; Gerardo Soria-Rodr&#xed ; guez^a ; Alejandro Soriano-Bautista^a ; Jaime Cadena-Valencia^a ; Jorge R. Bazá ; n-Fr&#xed ; as^a ; Nardhy Gó ; mez-Ló ; pez^b ; ^c ; Aurora Espejel-Nú ; ñ ; ez^b ; Felipe Vadillo-Ortega^d ; Karol Carrillo-Sá ; nchez^e ; Juan C. Verd&#xed ; n-Reyes^e ; Santiago March-Mifsut^e ; Mó ; nica Mé ; ndez-D&#xed ; az^f ; Oscar Prospé ; ro-Garc&#xed ; a^f
• 关键词：Procedural learning ; AATn ; CNR1 ; CB1 ; Striatum ; Memory
• 刊名：Neuroscience Letters
• 出版年：2011
• 出版时间：2 May 2011
• 年：2011
• 卷：494
• 期：3
• 页码：202-206
• 全文大小：160 K

文摘

Procedural learning refers to the acquisition of motor skills and the practice that refines their performance. The striatum participates in this learning through a function regulated by endocannabinoid signaling and other systems. This study relates the efficiency in learning a procedural task with the AATn polymorphism of the CNR1 gene, which encodes for the CB1 receptor. The mirror-drawing star task was solved by 99 healthy young subjects in three trials. The sample was divided into high- and low-performance groups based on performance efficiency. AAT12/14 carriers were more frequent in the former group, while there were more AAT12/13 carriers in the latter, which also made more errors/min. Therefore, we characterized two efficiency phenotypes: high- vs. low-performers associated with the two AATn genotypes, AAT12/14 vs. AAT12/13. The findings suggest that AATn polymorphism modifies CNR1 translation, indicating a different modulation of CB1.