Sedative, vasorelaxant, and cytotoxic effects of convolvulin from Ipomoea tyrianthina

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• 作者：Ismael Leó ; n-Rivera^a ; ^{ismaelr@uaem.mx"" rel=""nofollow} ; ^{ismaelr@ciq.uaem.mx"" rel=""nofollow} ; Maribel Herrera-Ruiz^e ; Samuel Estrada-Soto^b ; Mar&#xed ; a del Carmen Gutié ; rrez^c ; Ivá ; n Mart&#xed ; nez-Duncker^d ; Gabriel Navarrete-Vá ; zquez^b ; Mar&#xed ; a Yolanda Rios^a ; Berenice Aguilar^a ; Patricia Castillo-Españ ; a^c ; Alma Aguirre-Moreno^b
• 关键词：Ipomoea tyrianthina ; Resin glycoside ; Sedative ; Vasorelaxant ; Convolvulin ; Cytotoxic
• 刊名：Journal of Ethnopharmacology
• 出版年：2011
• 出版时间：17 May 2011
• 年：2011
• 卷：135
• 期：2
• 页码：434-439
• 全文大小：284 K

文摘

Aim of the study

Ipomoea tyrianthina has been used in Mexican traditional medicine as a mild purgative, for the treatment of nervous disorders, and against tumors. In this study, the effect of convolvulin (an ether-insoluble resin glycoside) from the root of Ipomoea tyrianthina on: Central Nervous System; as spasmolytic and vasodilator; cytotoxic against cancer cell lines is evaluated.

Materials and methods

Convolvulin isolated from the root of Ipomoea tyrianthina (IT-EM) was tested on pentylentetrazole induced seizures, pentobarbital-induced hypnosis, release of GABA and glutamic acid, isolated rat aorta and ileum rings, and against Caco-2 and KB cell lines.

Results

IT-EM increased the hypnotic effect induced by pentobarbital and the release of GABA in brain cortex of mice, but did not protect mice against pentylenetetrazole-induced convulsions. IT-EM produced a significant vasodilator effect in concentration- and endothelium-dependent manners on isolated rat aorta, but did not inhibit significantly contractions on rat ileum, colon, and jejune rings. IT-EM showed cytotoxic activity against nasopharyngeal carcinoma KB cell line.

Conclusions

Convolvulin (IT-EM) from Ipomoea tyrianthina has sedative effect, vasorelaxant effect in concentration- and endothelium-dependent manners, and cytotoxic activity against nasopharyngeal carcinoma KB cell line.