Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells

详细信息    查看全文

• 作者：Mario Negrette-Guzmá ; n^a ; Sara Huerta-Yepez^b ; Mario I. Vega^c ; Juan Carlos Leó ; n-Contreras^d ; Rogelio Herná ; ndez-Pando^d ; Omar Noel Medina-Campos^a ; Esteban Rodrí ; guez^b ; Edilia Tapia^e ; José ; Pedraza-Chaverri^a ; ^{pedraza@unam.mx}
• 关键词：Sulforaphane ; Mitochondrial biogenesis ; Mitochondrial dynamics ; Cell death ; Cancer ; Nuclear factor E2-related factor 2
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：90-102
• 全文大小：2840 K
• 卷排序：100

文摘

Sulforaphane (SFN) induces mitochondrial biogenesis in normal and cancer cells. SFN-induced mitochondrial biogenesis decreases cell viability in cancer cells. SFN modulates differentially mitochondrial dynamics in normal and cancer cells. Sulforaphane could be inducing a metabolic shifting in prostate cancer cells.