A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity
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- 作者：Gabriele Losi ; gabriele.losi@bio.unipd.it" class="auth_mail" title="E-mail the corresponding author ; gabrielelosi@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Iacopo Marcon ; Letizia Mariotti ; Michele Sessolo ; Angela Chiavegato ; Giorgio Carmignoto
- 关键词：Focal seizures ; Temporal cortex ; GABAergic interneurons ; Astrocytes
- 刊名：Journal of Neuroscience Methods
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：260
- 期：Complete
- 页码：125-131
- 全文大小：1496 K
文摘
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We propose a model of seizure-like events in temporal cortex slices from young mice.
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In the model local NMDA stimulations induce multiple seizure-like events.
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Electrophysiological, Ca2+ imaging and optogenetics are combined in the model.
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Seizures generation and propagation are separately studied.
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The role of specific cell population on these events can be accurately analyzed.